The 1974 Lausanne Congress was the first time leaders from the Global South were given a place among the world’s evangelical leadership. So when Latin American theologian René Padilla ascended the podium to give his address, he carried the hopes of the Global South with him. In honour of René’s passing on 27 April 2021, we bring to you the seminal address that set the 1974 Congress alight. His message rebuking worldly culture-Christianity and challenging the global church to move instead toward humility, theological renewal, and cross-fertilization remains timeless and especially prescient for us today.